Bisphosphonate drug holidays: Can we recommend currently?

Evaluation of fracture risk and potential drug holidays for postmenopausal women on long-term bisphosphonate therapy

STUDY OBJECTIVE To describe characteristics of postmenopausal women on long-term bisphosphonate therapy who fall into one of four fracture risk categories (low, mild, moderate, high), and to determine the prevalence of women eligible for a drug holiday. DESIGN Retrospective electronic health record review. SETTING Eight primary care clinics within a university-based health care system. PA...

Should we recommend PEC and when?

Percutaneous endoscopic colostomy (PEC) was first described in 1986, by Jeffrey Ponski [1], who had invented percutaneous endoscopic gastrostomy a few years before that [2]. Performed by 2 operators, PEC consists of placing a tube in the colon during colonoscopy in order to provide antegrade colonic enemas (ACE) in severe constipation or fecal incontinence [3,4]. The PEC tube can also be used a...

Pedometer accuracy for children: can we recommend them for our obese population?

OBJECTIVE In this study, we investigated the accuracy of measuring walking steps with commercially available pedometers and an accelerometer-based step-counter in normal and overweight children. Our primary hypothesis was that commercially available pedometers are not an accurate measure of walking steps in normal and overweight children while walking. Our secondary hypothesis was that the acce...

Drug safety during pregnancy : can we analyze teratogenic drug prescriptions ?

Objectives: To assess the extent to which teratogenic drugs are prescribed during pregnancy and to investigate. the feasibility of an alert system at the point of prescription, in order to improve drug safety during pregnancy. Methods: We establish a reference list of teratogenic drugs by merging lists of teratogenic drugs published in the literature, extract drug prescriptions to pregnant wome...

Can we now recommend hydrogen peroxide for pancreatic necrosectomy? Time for controlled data